Exercise Protects your Brain
A growing body of evidence suggests exercise can enhance brain function and reduce neuro-degeneration.
Exercise improves neuroplasticity via affecting synaptic structure and function in multiple brain regions
Exercise also helps to regulate neuroinflammation and glial activation.
Microglia and Pro-inflammatory cytokines play significant roles in the development of neurodegenerative disease, such as Alzheimer’s, Parkinsons, etc. .
Mee-inta, et al. (2019), highlighted the impacts of exercise on microglia activation, which offers potential to improve the brain health where pharmacological intervention has failed. .
When exposed to pathological insult, microglia transform from a resting stage into a spectrum of activated stages. ..
Activated microglia can lead to neuroinflammation, affecting neurogenesis, neuronal synaptic morphology, and synaptic plasticity.
*Exercise Regulates Microglial Activation by Increasing Anti-Inflammatory Factors, such as...
- Anti-inflammatory Cytokines
- CD200-CD200R - (immunomodulatory factor expressed by neurons in the brain).
- TREM2 - (Immunoglobulin receptor, reduced function can increase risk of Alzheimers)
- Heat Shock Proteins - (maintain cellular homeostasis and protein stability)
- Brain Derived Neurotrophic Factor - Can regulate neuronal cell survival, adult hippocampal neurogenesis, and neuroplasticity .
- Glymphatic System - ‘Brain waste system’
- Gut Microbiome - can influence the activation status of microglia, as well as performance of learning and memory. .
Low-intensity exercise can regulate microglial activation via expressions of various factors. .
Some of these factors subsequently prevent neuroinflammation in the CNS. .
Physical activity represents a natural strong anti-inflammatory strategy to improve brain function.
Mee-inta, O. et al. 2019. Physical Exercise Inhibits Inflammation and Microglial Activation. Cells 2019, 8, 691.