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@physicaltherapyresearch
784 Likes21 Comments
784 Likes21 Comments

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Exercise Protects your Brain
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INTRO
A growing body of evidence suggests exercise can enhance brain function and reduce neuro-degeneration.
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Exercise improves neuroplasticity via affecting synaptic structure and function in multiple brain regions
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Exercise also helps to regulate neuroinflammation and glial activation.
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Microglia and Pro-inflammatory cytokines play significant roles in the development of neurodegenerative disease, such as Alzheimer’s, Parkinsons, etc. .
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Mee-inta, et al. (2019), highlighted the impacts of exercise on microglia activation, which offers potential to improve the brain health where pharmacological intervention has failed. .
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HIGHLIGHTS
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MICROGLIA:
When exposed to pathological insult, microglia transform from a resting stage into a spectrum of activated stages. ..
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Activated microglia can lead to neuroinflammation, affecting neurogenesis, neuronal synaptic morphology, and synaptic plasticity.
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*Exercise Regulates Microglial Activation by Increasing Anti-Inflammatory Factors, such as...
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- Anti-inflammatory Cytokines
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- CD200-CD200R - (immunomodulatory factor expressed by neurons in the brain).
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- TREM2 - (Immunoglobulin receptor, reduced function can increase risk of Alzheimers)
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- Heat Shock Proteins - (maintain cellular homeostasis and protein stability)
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- Antioxidants
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- Brain Derived Neurotrophic Factor - Can regulate neuronal cell survival, adult hippocampal neurogenesis, and neuroplasticity .
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- Glymphatic System - β€˜Brain waste system’
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- Gut Microbiome - can influence the activation status of microglia, as well as performance of learning and memory. .
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CONCLUSIONS
Low-intensity exercise can regulate microglial activation via expressions of various factors. .
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Some of these factors subsequently prevent neuroinflammation in the CNS. .
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Physical activity represents a natural strong anti-inflammatory strategy to improve brain function.
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SOURCE:
Mee-inta, O. et al. 2019. Physical Exercise Inhibits Inflammation and Microglial Activation. Cells 2019, 8, 691.
PhotoCredit:unknown

22 Aug 2019

Comments
  • @alirezapaahoo

    what about type and intensity exercise?

    23 Aug 2019

  • @gatotwidd

    πŸŒŸπŸ‘Œ

    22 Aug 2019

  • @transformdigital

    What about when you get a concussion? If you’re consistently working out and being healthy do you recover more quickly from a concussion?

    22 Aug 2019

  • @aliyazdan93

    Not rugby lol

    22 Aug 2019

  • @o_stiggity

    @_waldenfit

    22 Aug 2019

  • @whispers1111

    @o_stiggity

    22 Aug 2019

  • @advantageptworks

    Yes def agree πŸ’―πŸ‘Œ

    22 Aug 2019

  • @r.igo

    @swankylocks

    22 Aug 2019

  • @alberto_baduini

    What about high intensity exercise ?

    22 Aug 2019

  • @trailrunnergmu

    πŸ™Œ

    22 Aug 2019

  • @demi_lj17

    @tina_the_traveller

    22 Aug 2019

  • @rarephysio

    Love it great breakdown πŸ‘πŸ»πŸ‘πŸ»πŸ‘πŸ»

    22 Aug 2019

  • @physicaltherapyresearch

    . . . . #rehab #pain #painscience #physiology #physicaltherapy #physiotherapy #massage #orthopedic #chiropractic #medicine #sportsmedicine #science #research #health #wellness #nervoussystem #neuroscience #brain #physicaltherapyresearch #dpt #dptstudent #exercise #fitness #workout #brain #braingains

    22 Aug 2019