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@physicaltherapyresearch
191 Likes21 Comments
191 Likes21 Comments

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Proton Pump Inhibitors: Reported Risks
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Proton pump inhibitors (PPIs) are among the most prescribed classes of drugs in this day and age.
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PPI’s are used for patients with an array of GI conditions, including:
Gastroesophageal reflux
Peptic ulcer disease
Helicobacter pylori infection
Barrett’s esophagus.
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Six PPIs are approved by the Food & Drug Administration (FDA): Omeprazole
Lansoprazole
Dexlansoprazole
Esomeprazole
Pantoprazole
Rabeprazole.
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Concerns continue to surface regarding their use and potential complications:
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Below are 10 Reported Concerns with PPI’s:

Bone Fracture:
Due to possible interference with the absorption of calcium salts and inhibition of bone remodeling.

Hypomagnesia:
Linked to cardiovascular and non-cardiovascular mortality, arrhythmias, muscle weakness, tetany, or convulsions.
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Iron Deficiency:
Suppression of acid potentially leading to malabsorption.

B12 Deficiency:
Inhibits the cleavage of vitamin B12 from dietary proteins, and reduces absorption.

Community Acquired Pneumonia:
Acid suppression has lead to increased risk.

Infection:
Higher pH, allowing bacteria, such as, C. Difficile, salmonella, etc. to remain stable and increase risk of infection. .

Kidney Disease
Linked to acute and chronic kidney disease as well as progression from chronic kidney disease to end-stage renal disease.

Heart Attack
Linked in acute cardiac events by inhibiting nitric oxide synthase activity.

Dementia & Alzheimers
Lower levels of protective vitamin B12 or direct inhibition of the enzymatic clearance of β-amyloid.
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Thoughts? Questions? Comments?
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Write them below. .
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SOURCE:
Brisebois et al.: Risks of Proton Pump Inhibitors. Laryngoscope Investigative Otolaryngology 3: December 2018.

14 Nov 2019

Comments
  • @deelacy3

    What alternative do you offer? What can be done?

    16 Nov 2019

  • @crowleycourtney

    Thank you✊

    15 Nov 2019

  • @hongster324

    Risks vs benefits should be discussed and one shouldn’t be terrified of a laundry list of side effects without context

    14 Nov 2019

  • @hongster324

    Absolutely no proof that PPIs cause renal disease or even exacerbate them, just people on them have higher creatinines probably because they’re just less healthy. Also could say similar things about lots of the things listed like heart attack. Other things are fair to discuss with a physician if it’s the right choice for them

    14 Nov 2019

  • @hongster324

    This post only lists cons and doesn’t reflect actual rates of these complications or if there has been proof of causation or rather just association with concurrent use. I’d like to respectfully point out that you may dissuade people from continuing use regardless of their potential need of this class of medication: ppl w/ GERD, peptic ulcer disease, history of fundoplication, etc.

    14 Nov 2019

  • @gelangford

    Yes already knew this, any suggestion to replace it?

    14 Nov 2019

  • @honey_infinitehealth_massage

    Then what can you do instead of taking these medication?

    14 Nov 2019

  • @tonecold96

    I was on omeprozole for a few months and I had to get off it, it made swallowing foods difficult and I just didn’t like it

    14 Nov 2019

  • @maybe_higareda

    @sattie.constantino

    14 Nov 2019

  • @fizyoterapist_varol

    Yeah we don't like medication but this age, science so much hardly accept medicationless treatment like diet, physiotherapy etc.

    14 Nov 2019

  • @buxomwench81

    You forgot oesphogeal cancer to the list

    14 Nov 2019

  • @physicaltherapyresearch

    . . . . #rehab #pain #painscience #physiology #physicaltherapy #physiotherapy #massage #orthopedic #chiropractic #medicine #sportsmedicine #science #research #health #wellness #nervoussystem #neuroscience #brain #physicaltherapyresearch #dpt #dptstudent #exercise #fitness #workout #ppi

    14 Nov 2019