Oxygen-Ozone Injection for Knee OA
Ozone (O3) gas is currently being injected to treat chronic pain relief in knee osteoarthritis (OA)
Injected O3 gas, is thought to improve pain and function in Knee OA through inhibition of the inflammatory process.
Sconza et al. (2019), systematically reviewed RCT’s, in the past 20 years, covering ozone intra-articular injection for the treatment of Knee OA. .
858 patients (629 female and 229 male).
Control groups included:
+Placebo (1 trial)
+Hyaluronic acid injection (2 studies)
+Hyaluronic acid & PRP injection (1 trial) +Corticosteroid injection (4 studies)
+Hypertonic dextrose, Radiofrequency, or Celecoxib + Glucosamine (3 trials). .
Quality of Studies:
Cochrane Risk of Bias Tool was Used
Good - 0
Fair - 2
Poor - 9 .
No major complications or serious adverse events were reported.
Encouraging pain relief at short-term. .
Encouraging pain relief mid-term.
On the basis of the available data, no clear indication emerged from the comparison with other established treatments for Knee OA.
Available research is of poor methodological quality.
Most studies flawed by relevant bias.
On the basis of the data available:
+Can be a safe approach
+Encouraging pain control and functional recovery in the short/middle term.
Thoughts? Questions? Comments?
Write them below. .
Sconza et al. 2019. Oxygen–Ozone Therapy for the Treatment of Knee Osteoarthritis: A Systematic Review of Randomized Controlled Trials. Arthroscopy.